“acme: [L16th] In Greek akme meant ‘point’ or ‘pinnacle, highest point.’ Its use dates from the late 15th century, although for the next hundred years or so it was consciously used as a Greek word and written in Greek letters. For many people their first exposure to the word comes from the ‘Looney Tunes’ cartoons featuring the Roadrunner and Wile E. Coyote, where the characters buy products from the Acme company. ‘Acme’ was a real brand name for various US firms in the last two decades of the 19th century, chosen in part because the word comes near the top of any alphabetical list of suppliers. Acne [M19th] the skin condition, has a similar root. The idea is that all those red pimples are little points sticking up from someone’s face.
Excerpted from: Creswell, Julia. Oxford Dictionary of Word Origins. New York: Oxford University Press, 2010.